New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride

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New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride.

Stable co-polymer [vinyl acetate-co-3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate, p(VA-co-DMAPS)] latex of different compositions has been synthesized for the first time by emulsifier-free emulsion copolymerization. The unusual >>overshooting<< behavior of the co-polymer tablets has been explained by the formation of specific clusters from the opposite oriented dipoles-zwitterion...

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ژورنال

عنوان ژورنال: Acta Pharmaceutica

سال: 2007

ISSN: 1846-9558,1330-0075

DOI: 10.2478/v10007-007-0034-4